Search results for "Chronic nicotine"

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Effects of chronic nicotine on the temporal structure of anxiety-related behavior in rats tested in hole-board.

2019

Abstract The present study aimed to assess the behavioral effects of chronic treatments of different doses of nicotine by using both quantitative and multivariate T-pattern analysis (TPA), which can reveal hidden behavioral structures, in Sprague-Dawley rats tested in the hole-board apparatus. To this purpose, nicotine ditartrate was administered at the doses of 0.1, 0.5 and 1 mg/kg i.p., three times per day, for 14 consecutive days. As to quantitative evaluations, we observed significant reductions in the mean durations and mean frequencies of walking, climbing, immobile-sniffing and rearing in comparison to control. A significant reduction of edge-sniff and head-dip mean frequencies was a…

MaleNicotineTime FactorsHole-boardmedicine.medical_treatmentQuantitative EvaluationsPhysiologyAnxietyMotor ActivityT-pattern analysisSettore BIO/09 - FisiologiaAnxiety; Chronic nicotine; Hole-board; Sprague-Dawley rats; T-pattern analysis; Animals; Anxiety; Dose-Response Relationship Drug; Drug Administration Schedule; Exploratory Behavior; Male; Motor Activity; Nicotine; Random Allocation; Rats; Rats Sprague-Dawley; Time FactorsDrug Administration ScheduleNicotineDose-Response RelationshipRats Sprague-Dawley03 medical and health sciencesSprague-Dawley ratRandom Allocation0302 clinical medicineSprague dawley ratsMedicineAnimalsBiological PsychiatryPharmacologyDose-Response Relationship Drugbusiness.industrySprague-Dawley rats030227 psychiatryRatsChronic nicotineChronic nicotineExploratory BehaviorSmoking cessationAnxietySprague-Dawleymedicine.symptomDrugbusinessmedicine.drugProgress in neuro-psychopharmacologybiological psychiatry
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Behavioral effects of combined environmental enrichment and chronic nicotine administration in male NMRI mice

2013

Abstract Environmental enrichment (EE) is an experimental paradigm which provides sensory, social, physical and cognitive stimulation for rodents. Experimental evidence indicates that this type of housing induces different neurobiological and behavioral changes. However, few studies have evaluated the consequences of combined exposure to an enriched environment and nicotine administration during a critical period of development such as adolescence. Taking into account previous studies, it can be hypothesized that a chronic treatment with nicotine would modulate the effects of rearing animals in enriched environments. In the current study, our main aim was to evaluate the effects of EE and c…

MaleNicotinemedicine.medical_specialtyTime FactorsDrinkingExperimental and Cognitive PsychologyEnvironmentInhibitory postsynaptic potentialDrug Administration ScheduleNicotineMiceBehavioral Neurosciencechemistry.chemical_compoundInternal medicineAnimals Outbred StrainsAvoidance LearningmedicineAnimalsNicotinic AgonistsCotinineMaze LearningAnalysis of VarianceEnvironmental enrichmentBehavior AnimalBody WeightInhibition PsychologicalEndocrinologyChronic nicotinechemistryNmri miceAnesthesiaExploratory BehaviorAnxietyCholinergicmedicine.symptomPsychologyCotinineLocomotionmedicine.drugPhysiology & Behavior
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